I just purchased, had same issues with my Nitro Mesh kit. Select ASIO for audio device, (I have Focusrite USB ASIO), Select “Use multi-out” under out channels, select and hit apply for Alesis Nitro under MIDI device, Midi Channel is “Any”. I then hit MENU, Settings –> EDrums –> MIDI Mapping selected Alesis Nitro/Surge and now it works!
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